Senior/Principal Scientist, Staff Scientist

Department: R&D
Location: South San Francisco


Nkarta Therapeutics, Inc. is a private biotech start-up that is harnessing the power of Natural Killer cells in developing next generation cellular immunotherapies for cancer. NK cells play a key role in the body’s immune system, able to identify and kill abnormal cells by monitoring their expression of activating and inhibitory receptors and recruit the adaptive immune system.

Nkarta will combine its NK expansion platform with further proprietary cell engineering technologies to build differentiated products designed to tackle challenging diseases with significant unmet clinical need.

We are currently offering a unique opportunity for a highly motivated researcher to join our team with experience in immune, cellular and cancer biology.


  • Leads in vivo Pharmacology function within the Pre-clinical Development Team including model development and validation that will be used for internal target validation/selection, and lead clinical candidate selection

  • Contributes to the Pharmacology strategy, data analyses, and presentations at internal and external meetings for multiple projects

  • Serves as external liaison to CROs and collaborators

  • Design and execute experiments independently; accurately record, analyze and communicate data to senior staff and team members.

  • Present results in team meetings and deliver presentations to both small and large groups.

  • Collaborate and coordinate studies with cross-function groups to optimize workflow

  • Serves as mentor and model to more junior members


  • Must have
    • PhD in immunology or related discipline with 2 or more years of industry experience after post-doctoral studies.

    • Experience running and establishing heme and solid tumour models including patient-derived and cell-line derived xenograft models

    • Highly collaborative with a keen scientific acumen

    • Strong verbal and writing skills for documentation of data, drafting of technical reports, and communication of progress to supervisor and project teams

    • Ability to multi-task and work within a fast-paced team environment

  • Preferred:
    • Experience with cellular therapy

    • Proficiency in designing and performing IND-enabling pharmacology studies including PK/PD, non-GLP toxicology, and biomarker discovery

    • Managerial and monitoring experience

    • Embodies the company culture of empowerment, diversity, and inclusion


Nkarta offers a creative, team-oriented scientific environment, along with a strong compensation package that includes salary, stock options, and a comprehensive benefits package.

To apply Attach your CV Here